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Laboratory Information Management Systems

LIMS - Laboratory Information Management Systems for Genetic Research
Laboratories that deal with Biological Tissue Samples for Genetic Research can be categorized in the following ways :

- The tissue procurement activity
- The tissue stabilization, pre processing and storage facility
- The analytical facility

The sample is linked to the demographics of the patient and their families so that the end analysis can be linked to the demographic information. This is a key requirement for both - searching for a subset of samples and linking the analysis to a demographic group.
Our web based software systems address all these areas. The researchers can interact with the lab managers and technicians for sending samples, requesting services and receiving analysis.

LIMS - The Tissue Procurement Activity
In a hospital oriented research organization, patients are located throughout the facility. Tissue Samples are derived as a result of a specific request and permission from these patients or as an offshoot of surgical procedures.
The researcher can either request the facility to procure certain tissues and when procured, the facility staff can inform the researcher that the tissue is procured. Additionally, the researcher can inform where the tissue is to be procured from, how it should be collected, in what aliquots it should be finally stored, where it should be sent and what analysis should be done on the sample.
The Tissues aliquots are bar coded for storage and tracking.
Typically, the tissues collected, partially processed and is either stored or sent to another lab for processing and analysis.

LIMS - Tissue Processing and Storage Facility
This application manages a laboratory that receives biological samples from researchers or other tissue procurement facilities and stores them after stabilizing them. The quality of the basic tissue sample is assured at this stage, due to appropriate handling, correct storage and record keeping.
The processed and stored tissue samples in this laboratory forms the basic inventory of genetic samples for a particular research protocol.
The demographics of the person, from whom the tissue sample was procured, is also recorded and maintained in a database. The final analysis of the Gene Sequence can be referenced back to the person from whom the sample was procured.
The samples are processed, bar coded and stored as Plasma, Parafin Embedded Tissue, OCT Embedded Tissue, or as Frozen Tissue.
On request, such laboratories process the samples and deliver the DNA, RNA, Raw DNA, EBV Cells, Cut Sections, OCT Embedded Tissue, etc. to the researcher ( or laboratory ) for use in the final analysis of the samples.

LIMS - The End Analysis Facility
The researcher will select samples from the inventory of stored Tissue Samples forming a part of the Genetic Core related to a Clinical Research Trials Protocol. The Tissue Samples are sent along with the demographic information so that the last stage of the analysis will also reference the same information. The selected samples are forwarded to laboratories that perform the following analysis:

- Gene Expression / Micro Array Analysis using Affymetrix machines and processes.
- Molecular Pathology Covering
  - In-situ Hybridization
  - Immuno-Histochemistry
  - Histology

The above mentioned processes involve a researcher asking for certain analysis (also referred to as protocols) and the laboratory staff carrying out the analysis and delivering the results to the researcher. The results are delivered by uploading to the central servers for remote access by the researcher. Billing to the researchers is also indicated by the software.

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